Patricia Smith Churchland. Patricia Smith Churchland is at the Philosophy Department, University of California, San Diego, La Jolla, CA 92092, USA. The ground is shifting under the traditional approaches to problems in the philosophy of mind. Earlier doctrines concernin & the independence of cognition from the brain now appear untenable. As neuroscience uncovers more about …
Mark R. Cobain a, John P. Foreyt b, a Unilever Corporate Research, Colworth House, Sharnbrook, Bedfordshire MK46 4AA, UK Abstract The central hypothesis examined in this issue is that insulin resistance promotes maladaptive brain function and contributes to reduced neuronal plasticity, potentially accelerating brain aging. Therefore, if we were to prevent or treat insulin resistance, …
Robert E. Burke. Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20895, USA. Abstract This chapter deals with the central role that Sir John Eccles played in the elucidation of the mechanisms of synaptic transmission within the central nervous system during the three decades between the …
Giacomo Rizzolattil and Laila Craighero. Dipartimento di Neuroscienze, Sezione di Fisiologia, via Volturno, 3, Universiti di Parma, 43100, Parma, Italy. Abstract A category of stimuli of great importance for primates, humans in particular, is that formed by actions done by other individuals. If we want to survive, we must understand the actions of others. Furthermore, …
Giovanni Buccino, MD, PhD,* Ana Solodkin, PhD,w and Steven L. Small, MD, PhDw Abstract Mirror neurons discharge during the execution of hand object-directed actions and during the observation of the same actions performed by other individuals. These neurons were first identified in the ventral premotor cortex (area F5) and later on in the inferior parietal …
Giovanni Buccino,a,* Ferdinand Binkofski,b and Lucia Riggioa a Dipartimento di Neuroscienze, Sezione di Fisiologia, Universita di Parma, Via Volturno 39, 43100 Parma, Italy Abstract Mirror neurons, first described in the rostral part of monkey ventral premotor cortex (area F5), discharge both when the animal performs a goal-directed hand action and when it observes another individual …
BRYAN KOLB*, MARGARET FORGIE, ROBBIN GIBB, GRAZYNA GORNY AND SHARON ROWNTREE Department of Psychology, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada. INTRODUCTION In principle, there are two ways that experience could alter the brain: either by modifying existing circuitry or by creating novel circuitry (63). It is reasonable to suppose that the brain makes …
Enrico Tongiorgi, Massimo Righi, and Antonino Cattaneo International School for Advanced Studies (SISSA), Neuroscience Program, 34014 Trieste, Italy. The mechanisms underlying the subcellular localization of neurotrophins and their receptors are poorly understood. We show that in cultured hippocampal neurons, the mRNAs for BDNF and TrkB have a somatodendritic localization, and we quantify the extent of …
Niraj S. Desai, Lana C. Rutherford and Gina G. Turrigiano; Department of Biology and Center for Complex Systems, Brandeis University, 415 South Street, Waltham, Massachusetts 02454-9110, USA During learning and development, the level of synaptic input received by cortical neurons may change dramatically. Given a limited range of possible firing rates, how do neurons maintain …
S, Goldman-Rakic, Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 In the presence of normal sensory and motor capacity, intelligent behavior is widely acknowledged to develop from the interaction of short- and long-term memory. While the behavioral, cellular, and molecular underpinnings of the long-term memory process have long been associated with …
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