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Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons (Fragment)

Enrico Tongiorgi, Massimo Righi, and Antonino Cattaneo International School for Advanced Studies (SISSA), Neuroscience Program, 34014 Trieste, Italy. The mechanisms underlying the subcellular localization of neurotrophins and their receptors are poorly understood. We show that in cultured hippocampal neurons, the mRNAs for BDNF and TrkB have a somatodendritic localization, and we quantify the extent of …

Plasticity in the intrinsic excitability of cortical pyramidal neurons (Fragment)

Niraj S. Desai, Lana C. Rutherford and Gina G. Turrigiano; Department of Biology and Center for Complex Systems, Brandeis University, 415 South Street, Waltham, Massachusetts 02454-9110, USA During learning and development, the level of synaptic input received by cortical neurons may change dramatically. Given a limited range of possible firing rates, how do neurons maintain …

Cellular Basis of Working Memory (Fragment)

S, Goldman-Rakic, Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 In the presence of normal sensory and motor capacity, intelligent behavior is widely acknowledged to develop from the interaction of short- and long-term memory. While the behavioral, cellular, and molecular underpinnings of the long-term memory process have long been associated with …

Facing others in pain: the effects of empathy (Fragment)

Goubert a,b,*,1, K.D. Craigc, T. Vervoort a,b,2, S. Morleyd, M.J.L. Sullivane, A.C. de C. Williams f, A. Canog, G. Crombeza,b aDepartment of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium bResearch Institute for Psychology & Health, Utrecht, The Netherlands Introduction A wealth of research addresses intra-individual determinants of pain, distress and disability. In contrast, limited …

Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states (Fragment)

Efstathios Garoflos†, Theofanis Panagiotaropoulos†, Stavroula Pondiki†, Antonios Stamatakis†, Eleni Philippidis and Fotini Stylianopoulou* Abstract In the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (GR), mineralocorticoid (MR) and type 1A serotonin (5-HT1A) receptors, as well as brain derived neurotrophic factor …

The role of the amygdala in human fear: Automatic detection of threat (Fragment)

Arne O¨ hman Psychology Section, Department of Clinical Neuroscience, Karolinska Institute and Hospital, 171 76 Stockholm, Sweden Summary Behavioral data suggest that fear stimuli automatically activate fear and capture attention. This effect is likely to be mediated by a subcortical brain network centered on the amygdala. Consistent with this view, brain imaging studies show that …

XXI Foro Norte de Investigación en Salud

El pasado 27 de mayo de 2015  Kinephy se encontró participando en el XXI Foro Norte de Investigación en Salud, lugar donde Investigadores, personal directivo, operativo y estudiantes del área de la salud del Instituto Mexicano del Seguro Social e instituciones públicas y privadas tuvieron un espacio de aprendizaje para la mejora continua. En este Foro, participamos en la …

XXI Foro Norte de Investigación en Salud

En estos momentos Kinephy se encuentra participando en el XXI Foro Norte de Investigación en Salud, lugar donde Investigadores, personal directivo, operativo y estudiantes del área de la salud del Instituto Mexicano del Seguro Social e instituciones públicas y privadas. Tienen un espacio de aprendizaje para la mejora continua. En este Foro, participamos en la presentación de …

Human brain mechanisms of pain perception and regulation in health and disease (Fragment)

Vania Apkarian a,*, M. Catherine Bushnell b, Rolf-Detlef Treede c, Jon-Kar Zubieta d a Department of Physiology, Northwestern University Medical School, 303 E. Chicago Avenue, Ward 5-003, Chicago, IL 60611, USA b Department of Anesthesia, McGill University, Montreal, Canada c Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany d Department of Psychiatry and …

Pain and the Neuromatrix in the Brain (Fragment)

Ronald Melzack, Ph.D. Abstract The neuromatrix theory of pain proposes that pain is a multidimensional experience produced by characteristic “neurosignature” patterns of nerve impulses generated by a widely distributed neural network—the “body-self neuromatrix”—in the brain. These neurosignature patterns may be triggered by sensory inputs, but they may also be generated independently of them. Acute pains …